How BEPREVE Works

BEPREVE Helps Block the Allergic Process

BEPREVE does this in 2 ways:

It blocks histamine (H₁)—the compound that triggers the allergic response—from attaching to receptors in cells that start the allergic reaction.¹
It stabilizes mast cells, which means it helps prevent these allergy cells from breaking down and releasing inflammation-causing substances.²

The diagram to the right shows that BEPREVE specifically blocks a receptor called H₁.¹ BEPREVE is less likely to bind to other receptor types, such as serotonergic, adrenergic, and muscarinic receptors, which may cause certain unwanted side effects like sedation (drowsiness), blurred vision, and dry mouth.^1,3,4

References: 1. Kato M, Nishida A, Aga Y, et al. pharmacokinetic and Pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate. Arzneimittelforschung. 1997;47(10):1116-1124. 2. Yato N, Murata T, Saito N, et al. Anti-allergic activity of betotastine besilate (TAU-284), a new anti-allergic drug. Nippon Yakurigaku Zasshi. 1997;110(1):19-29. 3. Crismon ML, Dorson PG. Schizophrenia. In: Dipiro T, ed. Pharmacotherapy: A Pathophysiologic Approach. Stamford, CT: Appleton & Lange; 1997:1367-1394. 4. Hawkins DW, Bussey HI, Trisant LM. Hypertension. In: Dipiro T, ed. Pharmacotherapy: A Pathophysiologic Approach. Stamford, CT: Appleton & Lange; 1997:195-218.

IMPORTANT SAFETY INFORMATION: BEPREVE is for topical ophthalmic use only. To minimize risk of contamination, do not touch the dropper tip to any surface. Keep the bottle closed when not in use. BEPREVE should not be used to treat contact lens–related irritation. Remove contact lenses prior to instillation of BEPREVE. The most common adverse reaction occurring in approximately 25% of patients was a mild taste following instillation. Other adverse reactions occurring in 2%-5% of patients were eye irritation, headache, and nasopharyngitis.