Click here to bypass content and jump to navigation

 

How BEPREVE Works

How BEPREVE Works

BEPREVE: A Selective Blocker of Histamine (H1)

BEPREVE has a dual mechanism of action

  • A topically active, highly selective, direct H1-receptor antagonist1
  • Mast cell stabilizer2

Bepotastine, the active ingredient of BEPREVE, does not bind to receptors that cause side effects typical of some other relievers1

  • It has low affinity to serotonergic, adrenergic, and muscarinic receptors3,4

References: 1. Kato M, Nishida A, Aga Y, et al. Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate. Arzneimittelforschung. 1997;47(10):1116-1124. 2. Yato N, Murata T, Saito N, et al. Anti-allergic activity of betotastine besilate (TAU-284), a new anti-allergic drug. Nippon Yakurigaku Zasshi. 1997;110(1):19-29. 3. Crismon ML, Dorson PG. Schizophrenia. In: Dipiro T, ed. Pharmacotherapy: A Pathophysiologic Approach. Stamford, CT: Appleton & Lange; 1997:1367-1394. 4. Hawkins DW, Bussey HI, Trisant LM. Hypertension. In: Dipiro T, ed. Pharmacotherapy: A Pathophysiologic Approach. Stamford, CT: Appleton & Lange; 1997:195-218.

Back to Top

IMPORTANT SAFETY INFORMATION: BEPREVE is for topical ophthalmic use only. To minimize risk of contamination, do not touch the dropper tip to any surface. Keep the bottle closed when not in use. BEPREVE should not be used to treat contact lens–related irritation. Remove contact lenses prior to instillation of BEPREVE. The most common adverse reaction occurring in approximately 25% of patients was a mild taste following instillation. Other adverse reactions occurring in 2%-5% of patients were eye irritation, headache, and nasopharyngitis.